In Vivo Effects of Nanotechnologically Synthesized and Characterized Fluoridated Strontium Apatite Nanoparticles in the Surgical Treatment of Endodontic Bone Lesions

In this study, fluoridated strontium apatite (SAP) nanoparticles with different mole percentages (5%, 10%, 30%, and 50%) synthesized using a hydrothermal method were used as biomaterials. The in vivo biocompatibility of the was investigated by embedding them biomaterials bone defects created rat tibiae. Through hematoxylin-eosin staining method, histopathological analysis performed for new formation, osteoblast density, fibrotic tissue formation. Fluorine (F) addition affected structural morphological properties nanoparticles. With F doping, shapes changed from nano-rods to almost spherical. Sr/P ratios, stoichiometric value 1.67, 1.76, 1.53, 1.54, 1.68, 1.79 pure, 5%, 50% F-doped nanoparticles, respectively. F/Sr ratios 0.05, 0.13, 0.16, 0.20, highest values terms formation obtained group containing pure SAP. best results density observed groups higher (30% F-doped). Pure showed good levels compared control group. It that an increase fluorine ratio resulted better healing. SAP can be orthopedics dentistry, especially surgical treatment endodontic lesions.